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Literature summary extracted from
- Azole drugs trap cytochrome P450 EryK in alternative conformational states (2010), Biochemistry, 49, 9199-9206.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.13.154 | recombinant His-tagged EryK is overexpressed in BL21 STAR (DE3) Escherichia coli strain | Saccharopolyspora erythraea |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.14.13.154 | crystal structures of EryK in complex with the azole inhibitors ketoconazole and clotrimazole | Saccharopolyspora erythraea |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.154 | clotrimazole | induces a distortion of the internal helix I that affects the accessibility of the binding pocket by regulating the kink of the external helix G via a network of interactions that involves helix F | Saccharopolyspora erythraea |  |
| 1.14.13.154 | ketoconazole | induces a distortion of the internal helix I that affects the accessibility of the binding pocket by regulating the kink of the external helix G via a network of interactions that involves helix F | Saccharopolyspora erythraea | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.154 | Saccharopolyspora erythraea | P48635 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.13.154 | - |
Saccharopolyspora erythraea |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.154 | EryK | - |
Saccharopolyspora erythraea |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.154 | cytochrome P-450 | a heme-thiolate protein (P-450) | Saccharopolyspora erythraea |
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Release 2023.1 (January 2023)
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